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| Registros recuperados: 104 | |
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| Mandal,Anurup; Sinha,Chandrima; Jena,Aditya Kumar; Ghosh,Soma; Samanta,Amalesh. |
| The antidepressant drug amitriptyline hydrochloride was obtained in a dry powder form and was screened against 253 strains of bacteria which included 72 Gram positive and 181 Gram negative bacteria and against 5 fungal strains. The minimum inhibitory concentration (MIC) was determined by inoculating a loopful of an overnight peptone water culture of the organism on nutrient agar plates containing increasing concentrations of amitriptyline hydrochloride (0, 10 µg/mL, 25 µg/mL, 50 µg/mL, 100 µg/mL, 200 µg/mL). Amitriptyline hydrochloride exhibited significant action against both Gram positive and Gram negative bacteria at 25-200 µg/mL. In the in vivo studies it was seen that amitriptyline hydrochloride at a concentration of 25 µg/g and 30 µg/g body weight of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amitriptyline hydrochloride; Antimicrobial activity; Non antibiotics. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000300014 |
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| Manilal,A; Sujith,S; Selvin,J; Shakir,C; Seghal Kiran,G. |
| The antibacterial property of the red algae, Falkenbergia hillebrandii (Born) collected from the southwest coast of India (Indian Ocean) was evaluated against three multidrug resistant human pathogens. Four different solvents: ethyl acetate, dichloromethane, methanol and phosphate buffer saline (PBS) were used with this purpose. Dried samples extracted with methanol showed broadest and highest antimicrobial activity when compared to other solvents. However, PBS extract showed no antibacterial activity. The highly active compounds red alga, F. hillebrandii were fractionated and purified using different chromatographic systems, including reverse phase HPLC and GCMS. The analysis revealed that the most abundant metabolite was the oleic acid (51.33%) followed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; F. hillebrandii; Multidrug resistant human pathogens; Methanolic extract; Bioactive compounds. |
| Ano: 2009 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572009000200013 |
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| Nascimento,Gislene G. F.; Locatelli,Juliana; Freitas,Paulo C.; Silva,Giuliana L.. |
| The antimicrobial activity of plant extracts and phytochemicals was evaluated with antibiotic susceptible and resistant microorganisms. In addition, the possible synergistic effects when associated with antibiotics were studied. Extracts from the following plants were utilized: Achillea millifolium (yarrow), Caryophyllus aromaticus (clove), Melissa offficinalis (lemon-balm), Ocimun basilucum (basil), Psidium guajava (guava), Punica granatum (pomegranate), Rosmarinus officinalis (rosemary), Salvia officinalis (sage), Syzygyum joabolanum (jambolan) and Thymus vulgaris (thyme). The phytochemicals benzoic acid, cinnamic acid, eugenol and farnesol were also utilized. The highest antimicrobial potentials were observed for the extracts of Caryophyllus aromaticus... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Plant extracts activity; Medicinal plants; Antimicrobial activity. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822000000400003 |
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| Benli,M; Yigit,N. |
| Since the number of microorganisms that are resistant to antibiotics has been increasing steadily, the need for combating these pathogens requires new pharmaceutical agents. To produce these substances, new models have been developed in recent decades. In our study, the venom of Agelena labyrinthica (Clerck, 1757) (Araneae: Agelenidae) was tested against ten bacterial strains, specifically, testing 1/100, 1/10 and 1/1 fractions of diluted venom against these bacteria. While the 1/100 dilution was successful in only one of ten bacterial strains, the 1/10 and the 1/1 were effective on six of ten bacterial strains. The most effective results, among these three different concentrations, were observed on Bacillus subtilis. The other five strains that were also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Agelena labyrinthica; Venom; Antimicrobial activity. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400007 |
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| Radaelli,Marcela; Silva,Bárbara Parraga da; Weidlich,Luciana; Hoehne,Lucélia; Flach,Adriana; Costa,Luiz Antonio Mendonça Alves da; Ethur,Eduardo Miranda. |
| Abstract Despite recent advances in food production technology, food-borne diseases (FBD) remain a challenging public health concern. In several countries, including Brazil, Clostridium perfringens is among the five main causative agents of food-borne diseases. The present study determines antimicrobial activities of essential oils of six condiments commonly used in Brazil, viz., Ocimum basilicum L. (basil), Rosmarinus officinalis L. (rosemary), Origanum majorana L. (marjoram), Mentha × piperita L. var. Piperita (peppermint), Thymus vulgaris L. (thyme) and Pimpinella anisum L. (anise) against C. perfringens strain A. Chemical compositions of the oils were determined by GC–MS (gas chromatography–mass spectrometry). The identities of the isolated compounds... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Food-borne disease; Antimicrobial activity; Clostridium perfringens; Spices; Essential oils. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000200424 |
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| Lima,Matheus Thomaz Nogueira Silva; Santos,Larissa Batista dos; Bastos,Rafael Wesley; Nicoli,Jacques Robert; Takahashi,Jacqueline Aparecida. |
| ABSTRACT Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Acetylcholinesterase inhibition; Epigenetic modulation; Penicillium sp.; Talaromyces sp.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000100169 |
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| Martinelli,Laira; Rosa,Jessica Miranda; Ferreira,Carolina dos Santos Bragine; Nascimento,Gustavo Marcelo da Luz; Freitas,Mateus Silveira; Pizato,Luiz Carlos; Santos,Wanderson de Oliveira; Pires,Ricardo Francisco; Okura,Mônica Hitomi; Malpass,Geoffroy Roger Pointer; Granato,Ana Claudia. |
| ABSTRACT: Essential oils are the most important compounds produced during secondary metabolism in aromatic plants. Essential oils are volatile, have characteristic odor and are used as defensive agents by plants. In pepper, it is possible to say that essential oils are the “flavor fingerprint” of each species. In the present article, eight species of pepper were studied in order to extract their essential oils and oleoresins, test their antibacterial and antifungal activities and also to identify the compounds present in the most bioactive samples. Results demonstrated that two essential oils [Pimenta dioica (L.) Merr. and Schinus terebinthifolius] and three oleoresins (Schinus terebinthifolius and Piper nigrum white and black) recorded significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Peppers; Essential oil; Oleoresins; Antimicrobial activity; GC-MS. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000500451 |
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| Rechenchoski,Daniele Zendrini; Dambrozio,Angélica Marim Lopes; Vivan,Ana Carolina Polano; Schuroff,Paulo Alfonso; Burgos,Tatiane das Neves; Pelisson,Marsileni; Perugini,Marcia Regina Eches; Vespero,Eliana Carolina. |
| Abstract The production of KPC (Klebsiella pneumoniae carbapenemase) is the major mechanism of resistance to carbapenem agents in enterobacterias. In this context, forty KPC-producing Enterobacter spp. clinical isolates were studied. It was evaluated the activity of antimicrobial agents: polymyxin B, tigecycline, ertapenem, imipenem and meropenem, and was performed a comparison of the methodologies used to determine the susceptibility: broth microdilution, Etest® (bioMérieux), Vitek 2® automated system (bioMérieux) and disc diffusion. It was calculated the minimum inhibitory concentration (MIC) for each antimicrobial and polymyxin B showed the lowest concentrations for broth microdilution. Errors also were calculated among the techniques, tigecycline and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Enterobacter spp.; KPC; Methods of susceptibility. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000300509 |
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| Torres,AFC; Dantas,RT; Menezes,RRPPB; Toyama,MH; Filho,ED; Oliveira,MF; Nogueira,NAP; Oliveira,MR; Monteiro,HSA; Martins,AMC. |
| Some snake venom proteins present enzymatic activities, such as L-amino acid oxidase (LAAO). The aim of this paper was to investigate the effect of Bothrops leucurus total venom (BleuTV) and its fraction LAAO (BleuLAAO) on bacteria, yeast, and promastigote forms of Leishmania amazonensis and Leishmania chagasi, and epimastigote forms of Trypanosoma cruzi. BleuTV was isolated with a Protein Pack 5PW® (Waters Corporation, USA), and several fractions were obtained. BleuLAAO was purified to high molecular homogeneity, and its N-terminal amino acid sequence shared a high degree of amino acid conservation with other LAAOs. BleuTV inhibited Staphylococcus aureus growth in a dose-dependent manner, with a minimum inhibitory concentration (MIC) of 25 μg/mL, which... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: L-amino oxidase; Bothrops leucurus; Antimicrobial activity. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000400012 |
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| Custódio,Dayana Lacerda; Burgo,Rafaela Pinheiro; Moriel,Bárbara; Barbosa,Aneli de Melo; Rezende,Maria Ines; Daniel,Juliana Feijó de Souza; Pinto,Jurandir Pereira; Bianchini,Edmilson; Faria,Terezinha de Jesus. |
| The present study describes the chemical composition and antimicrobial activity of essential oils obtained by hydrodistillation from the leaves of Pimenta pseudocaryophyllus (1.0% w/w) and Tynanthus micranthus (1.1% w/w). GC and GC/MS analysis demonstrated that eugenol was the only component in the T. micranthus essential oil (99.9%) and the major component in the P. pseudocaryophyllus essential oil (92.59%), which also presented methyleugenol, terpinen-4-ol, o-cymene and (E)-caryophyllene, among others. Both the oils presented antimicrobial activity against bacteria, yeast and filamentous fungi tested.The Bioautography test revealed that eugenol was the bioactive component in both the oils against Cladosporium herbarum. This is the first report about the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pimenta pseudocaryophyllus; Tynanthus micranthus; Essential oil; Antimicrobial activity. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600013 |
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| Fernandes,Paulo André Vicente; Arruda,Isabel Renata de; Santos,Antônio Fernando Amatto Botelho dos; Araújo,Ana Albertina de; Maior,Ana Maria Souto; Ximenes,Eulália Azevedo. |
| Lipopeptides represent a class of microbial surfactants with increasing scientific, therapeutic and biotechnological interests. The genus Bacillus is a producer of these active compounds, and among them B. subtilis produces surfactin, the most potent biosurfactant known. These compounds can act as antibiotics, antivirals, antitumorals, immunomodulators and enzyme inhibitors. In this work, the antimicrobial activity of biosurfactants obtained by cultivation of B. subtilis R14 was investigated against multidrug-resistant bacteria. During cultivation in defined medium, the surface tension of the medium was reduced from 54 mN/m in the beginning of the microbial growth to 30 mN/m after 20 hours. A crude surfactant concentration of 2.0 g/L was obtained after 40... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biosurfactant; Bacillus subtilis; Lipopeptides; Antimicrobial activity. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000400022 |
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| Oliveira,Guilherme Ferreira de; Furtado,Niege Araçari Jacometti Cardoso; Silva Filho,Ademar Alves da; Martins,Carlos Henrique Gomes; Bastos,Jairo Kenupp; Cunha,Wilson Roberto; Silva,Márcio Luís de Andrade e. |
| The antimicrobial activity of Syzygium cumini leaves extract, known as "jambolão", was evaluated. The crude hydroalcoholic extract was active against Candida krusei (inhibition zone of 14.7 ± 0.3 mm and MIC = 70 µg/mL), and against multi-resistant strains of Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Disk diffusion method; Microdilution broth method; Multi-resistant strains; Syzygium cumini. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000200035 |
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| Botelho,M.A.; Nogueira,N.A.P.; Bastos,G.M.; Fonseca,S.G.C.; Lemos,T.L.G.; Matos,F.J.A.; Montenegro,D.; Heukelbach,J.; Rao,V.S.; Brito,G.A.C.. |
| Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated with respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrim-pimenta" is a typical shrub commonly found in the Northeast of Brazil. Many plant species belonging to the genus Lippia yield very fragrant essential oils of potential economic value which are used by the industry for the commercial production of perfumes, creams, lotions, and deodorants. Since the leaves of L. sidoides are also extensively used in popular medicine for the treatment of skin wounds and cuts, the objective of the present study was to evaluate the composition and antimicrobial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lippia sidoides; Essential oil; Antimicrobial activity; Oral pathogens. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300010 |
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| Registros recuperados: 104 | |
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